As of 2025, the bispecific antibody (BsAb) market exceeds USD 10 billion, fueled by multiple FDA approvals and 300+ clinical candidates. BsAbs now go beyond T-cell engagers to include NK cell engagers, dual checkpoint inhibitors, receptor clustering agents, and tumor-targeted cytokines, with formats ranging from IgG-like to trispecific and Fc-silent designs.
With innovation spanning discovery, process development, and manufacturing, understanding the full bsAb development continuum is critical. For scientists, developers, and decision-makers, learning this integrated landscape is essential to reduce R&D risk, accelerate timelines, and capture opportunity in one of the most competitive and transformative biologics sectors today.
🔬What to Learn:
1. Start Strong with BsAb Discovery
White Paper: How to Design and Evaluate BsAbs
- What are BsAbs?
- How to design discovery strategies based on structure?
- How to evaluate BsAbs comprehensively by MOA?
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2. Reliable Cell line development
Poster: Optimized Vector System for BsAb Expression in CHO-K1 Cells
White Paper: Cell Line Development Strategies for BsAb Manufacturing
3. Accelerated CMC Development
Folding: From Sequence to Tox DS Release in 7 Months for Symmetrical BsAb
White paper: Analytical Approach for BsAb Quality Study
4. Smooth tech transfer and qualified manufacturing
Handbook: Tech Transfer Manual
Folding: GMP Manufacturing Solutions
5. Proven Success
By providing a comprehensive suite of CMC development and IND dossier services, ProBio supported IMBiologics in obtaining FDA clearance and achieving a smooth license-out.
- 2023 ProBio Congratulates IMBiologics on FDA Clearance of IND Application for Innovative Bispecific Antibody Drug Project (IMB-101)
- 2024 IMBiologics Licenses $925mn Antibody Treatment (IMB-101) to Navigator Medicines
6. On-demand webinar
- Multiple Solutions of Functional Leads Discovery and Engineering
- ProBox™ Platform for Complex Biologics CMC Development
- Navigating Biologics Challenges：Regulatory, Process Development, and Tech Transfer Solutions
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Jessica Tu
Regional Marketing Manager
ProBio
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